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Swayam Central

NMR spectroscopy for Chemists and Biologists

By Prof. Ashutosh Kumar & Prof. Hosur   |   IIT Bombay
This course will start with Basic principles of NMR, walk through the analysis of spectra and demonstrate the application of multidimensional NMR spectroscopy in Chemistry and structural Biology. 

INTENDED AUDIENCE: M. Sc./ PhD and Scientists working in Pharma and Biophrma Industries
PREREQUISITES:          Under graduate level understanding of Physics and Mathematics
INDUSTRY SUPPORT : Biocon, Wockhardt, Aurobindo Biopharma etc

SUMMARY

Course Status : Upcoming
Course Type : Elective
Duration : 12 weeks
Start Date : 29 Jul 2019
End Date : 18 Oct 2019
Exam Date : 16 Nov 2019
Category :
  • Maths and Sciences
  • Level : Postgraduate
    This is an AICTE approved FDP course

    COURSE LAYOUT

    Week 1 :
    • Nuclear Spin and Magnetic Moments 
    • Nuclear Spins in a Magnetic Field Spin 
    • Lattice Relaxation Spin temperature Resonance 
    • Absorption of Energy and The NMR Experiment Resonance 
    • Absorption of Energy and The NMR Experiment Kinetics of Resonance Absorption
    Week 2 :
    • Selection Rules and Line widths 
    • Bloch equations
    • More about relaxation 
    • More about relaxation Sensitivity
    Week 3 :
    • Instruction to operator Algebra 
    • Chemical Shift
    • Anisotropy of chemical shifts Learning spectral simulation 
    Week 4 :
    • Factors Influencing Isotropic Chemical shifts: Spin Spin Coupling 
    • Analysis of NMR spectra of molecules 
    • Learning spectral simulation
    Week 5 :
    • Dynamic Effects in the NMR spectra : Two site exchange
    • Collapse of spin multiplets
    • Conformational Averaging of J- values
    • Analysis of NMR spectra of molecules with J Values 
    Week 6 :
    • Principles of Fourier transform
    • NMR Theorems on Fourier transforms
    • Practical aspects of recording FTNMR spectra
    • Free Induction Decay (FID) and the spectrum
    • Pulse repetition rate
    • Folding of signals
    • Acquisition time and the resolution
    • Data processing in FT
    • NMR Learning of Data processing 
    Week 7 :
    • Dynamic range in FTNMR and solvent suppression
    • The Nuclear Overhauser Effect - Experimental Schemes,Advanced Treatment
    • Steady state NOE and Transient NOE 
    Week 8 :
    • Spin Echo Uncoupled spins
    • Spin Echo Coupled spins
    • Spin-lattice relaxation
    • Spin-spin relaxation
    • Polarization transfer SPT and INEPT spectral simulation
    Week 9 :
    • Density matrix, Elements of Density Matrix, Time evolution of density operator 
    • Time evolution of density operator 
    • Product operator formalism 
    Week 10 :
    • Segmentation of the time axis
    • Two dimensional NMR 2D
    • Fourier Transformation in NMR
    • Peak shapes in 2D spectrum
    • Quadrature detection in two-dimensional NMR 
    Week 11 :
    • 2D- resolution/ separation experiments
    • Two-dimensional correlation experiments COSY, TDQ-COSY etc TOCSY
    Week 12 :
    • 2D NOESY, 2D ROESY, Heteronuclear COSY,
    • The HETCOR pulse sequence HSQC 


    BOOKS AND REFERENCES

    1. NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry by Herald Gunther 
    2. NMR spectroscopy by RK Harris
    3. Protein NMR spectroscopy: Principles and Practice Arthur G. Palmer, III, John Cavanagh, Nicholas J. Skelton, and Wayne J. Fairbrother 
    4. Spin Dynamics by M.H. Levitt

    INSTRUCTOR BIO



    Prof. Ashutosh Kumar
    is working as Associate Professor in the Department of Biosciences and Bioengineering, IIT Bombay. His research area in NMR based structural Biology. 




    Prof. Hosur
    is Distinguished Visiting Professor in the Department of Biosciences and Bioengineering, IIT Bombay. Prior to this, he was senior Professor in Tata Institute of Fundamental Reseach, Mumbai

    COURSE CERTIFICATE

    • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
    • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
    • Date and Time of Exams : 16th November 2019 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
    • Registration url: Announcements will be made when the registration form is open for registrations.
    • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
    • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

    CRITERIA TO GET A CERTIFICATE
    • Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course. 
    • Exam score = 75% of the proctored certification exam score out of 100
    • Final score = Average assignment score + Exam score

    YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75
    • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
    • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay. It will be e-verifiable at nptel.ac.in/noc.
    • Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched

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