Biophysical chemistry

By Prof. Pramit K Chowdhury | IIT Delhi

Learners enrolled: 496

This introductory course in biophysical chemistry touches on some of the fundamentals of this field. Starting from basic elements in protein structure, the course covers other aspects like forces involved in protein folding, protein folding energy landscape, mechanisms of protein folding, mixing and relaxation techniques commonly used to study fast protein folding, and finally winds up with discussion on some spectroscopic tools (Absorption, Fluorescence and IR) that are very popular in the field of proteins.

INTENDED AUDIENCE: Post-Graduate Level and Above

PRE-REQUISITES : Basic Course in Physical Chemistry

Summary

Course Status :	Completed
Course Type :	Elective
Duration :	12 weeks
Category :	Chemistry
Credit Points :	3
Level :	Postgraduate
Start Date :	29 Jul 2019
End Date :	30 Nov 2019
Exam Date :	17 Nov 2019 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1: Introduction to Protein Structure (Lectures 1 and 2),

Secondary and Tertiary Structure of Proteins (Lectures 3, 4 and 5)

Week 2: Forces in Protein Folding 1 (Lectures 6, 7 and 8)

Week 3: Forces in Protein Folding 2 (Lectures 9, 10 and 11)

Week 4: Forces in Protein Folding 3 (Lectures 12, 13 and 14-part)

Protein Denaturation 2 (Lectures 17, 18 and 19-part)

Week 5: Protein Denaturation 1 (Lectures 14, 15 and 16)

Week 6: Protein Folding Pathways (Lectures 19 and 20)

Diffusion 1 (Lectures 21, 22 and 23)

Week 7: Diffusion 2 (Lectures 24, 25 and 26-part)

Electrochemical Potential (Lectures 26, and 27-part)

Week 8: Nucleation Mechanism (Lectures 27 and 28)

Mutational Analyses (Lectures 28, 29, 30 and 31-part)

Week 9: Protein Folding Kinetics 1 – Rapid Mixing (Lectures 31, 32, and 33-part)

Protein Folding Kinetics 2 – Relaxation Techniques(Lectures 33, and 34)

Week 10: Experimental Tools 1 (Lectures 35, 36, 37 and 38-part)

Week 11: Experimental Tools 2 (Lectures 38, 39, and 40)

Week 12: Experimental Tools 3 (Lectures 41 and 42)

Books and references

Nil

Instructor bio

Prof. Pramit K Chowdhury works on protein folding and dynamics using a range of spectroscopic techniques.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 17 November 2019, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100
Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75.

If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Madras. It will be e-verifiable at nptel.ac.in/noc.
Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched

SWAYAM Helpline / Support