Electronic Systems for Cancer Diagnosis

By Prof. Hardik Jeetendra Pandya | IISc Bangalore

Learners enrolled: 1928

This course is designed with an aim of educating students on the process flow for designing electronic systems for tissue-based cancer diagnosis. An exposure towards developing strategies to discriminate pathological cells from normal ones based on the electrophysiological properties of cells. Design and integrate biochip with electronic module for understanding the electro-thermo-mechanical properties of tissues. microtechnology and its use to fabricate sensors and systems. Students will have an exposure towards how to fabricate the sensors and its application in real world. Several examples of engineering devices used in clinical research will be also covered. Both conventional (class 1000) and non-conventional (class 10000) clean room and some equipment within it will also be shown. Below are some of the course outcomes.The first objective of this course is to understand cancer and its properties: Breast Cancer and Oral CancerThe second objective is to educate the students on the process flow for designing electronic systems for tissue-based cancer diagnosisThe third objective is to develop skills to design electronic systems for cytology-based studiesFourth objective is to develop skills to integrate biochips with electronic system for cancer diagnosisThe fifth objective is to understand how to work in a conventional (class 1000) and non-conventional (class 10000) clean room environment and understand several equipmentsThe final objective is to learn and understand in detail how to design electronic systems with the preexisting knowledge of basic electronics and to add on the 3D printing skills.

INTENDED AUDIENCE : Engineering Students, Faculty from Engineering Colleges

PREREQUISITES : Basic Electronics/Microfabrication

INDUSTRY SUPPORT : NILL

Summary

Course Status :	Completed
Course Type :	Elective
Duration :	12 weeks
Category :	Electrical, Electronics and Communications Engineering
Credit Points :	3
Level :	Undergraduate/Postgraduate
Start Date :	27 Jan 2020
End Date :	17 Apr 2020
Enrollment Ends :	03 Feb 2020
Exam Date :	26 Apr 2020 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1  : Introduction to tissue related cancers (Focusing on Breast Cancer and Oral Cancer)Current Gold Standards
Week 2  : Understanding the change in cells or tissue morphology.Developing strategies for diagnosis based on Morphology changes.
Week 3  : Basics of tissue culture methods: Types of cell growth, Work area and equipment (Laminar flow hoods, CO2 incubators, Microscopes, Preservation, Vessels, Storage)
Week 4  : Maintaining cells (harvesting, media and growth requirements), Safety considerations, Cell counting
Week 5  : Understanding 3D Printing and its use as packaging and press-fit contacts in electronic systems for cancer diagnosis
Week 6  : Hands-on experience in designing a 3D printed casing for electronic system packaging
Week 7  : Process for designing electronic system for early diagnosis of cancer based on tissue images
Week 8  : Process for designing electronic systems for cytology studies (cell extraction, scanning and image capturing).
Week 9  : Electronic Systems integrated with Biochip for understanding change in electro-thermo-mechanical properties of tissue
Week 10  : Working in a Clean Room (non-conventional Class 10000) and inspection of Cancer Diagnosis Tool with a basic training of operating the tools
Week 11  : Hands-on experience on lithography
Week 12  : Hands-on experience on wet-bench

Books and references

Lecture notes on some topics will be provided by the instructorJ.D. Plummer, M.D. Deal, P.G. Griffin, Silicon VLSI Technology, Pearson Education, 2001.S.A. Campbell, The Science and Engineering of Microelectronic Fabrication, Oxford University Press, 2001.S.M. Sze (Ed), VLSI Technology, 2nd Edition, McGraw Hill, 1988Senturia S. D., Microsystem Design, Kluwer Academic Publisher, 2001Madou, M Fundamentals of Microfabrication, CRC Press, 1997.Gad-el-Hak, M., Ed.; The MEMS Handbook; CRC Press: New York, NY, 2002.Mather J. P., Roberts P. E., Introduction to Cell and Tissue Culture, Springer, 1997.M. C. Phelan, UNIT 1.1 Basic Techniques for Mammalian Cell Tissue Culture, John Wiley and Sons, Inc, 2001.

Instructor bio

Prof. Hardik Jeetendra Pandya

IISc Bangalore

Biodata (Self Introduction): Dr. Hardik J. Pandya is an assistant professor in the Department of Electronic Systems Engineering, Division of Electrical Sciences, IISc Bangalore where he is developing Advanced Microsystems and Biomedical Devices Facility for Clinical Research and Biomedical and Electronic (10-6-10-9) Engineering Systems Laboratory to carry out cutting-edge research on novel devices to solve unmet problems in biology and medicine. He is recipient of prestigious Early Career Research Award from Science and Engineering Research Board, Government of India as well as a start-up grant of 228 Lacs from IISc. He has taught Design for Analog Circuits, Analog Integrated Circuits, VLSI technology, and Semiconductor Devices to undergraduate and graduate students from Electronic Engineering, Instrumentation Engineering, and Applied Physics. He seek to understand and exploit novel ways of fabricating microengineering devices using glass, silicon, polymers and integrate with unusual classes of micro/nanomaterials. His research interests include integrating biology/medicine with micro- and nanotechnology to develop innovative tools to solve unmet clinical problems. His current research focuses on flexible sensors for smart catheters, microsensors, microfluidic devices, and microelectromechanical systems, all lately with an emphasis on cancer diagnosis, therapeutics, e-nose, and biomedical device technologies. Before joining IISc, he worked as a postdoctoral scientist in the Department of Mechanical Engineering, Maryland Robotics Center, University of Maryland, College Park and in the Department of Medicine, Brigham and Women’s Hospital–Harvard Medical School affiliated with Harvard-MIT Health Science and Technology. His work has resulted in several patents and publications. His work has been highlighted as “Breaking Research News” by The Physicians Committee for Responsible Medicine and has been featured on IEEE Transactions on Biomedical Engineering July 2016 issue cover image as well as IEEE TBME July 2016 feature article for the website and monthly highlights. The work on portable cancer diagnosis tool was also featured on Science Translational Medicine as an Editorial Choice, Breast Cancer Diagnosis, March 2016 and has been highlighted on CapeRay blog as “Biochips and Diagnostic tools” in April 2016. His work has been published in high-quality journals including Lab on a Chip, IEEE Transactions on Biomedical Engineering, IEEE Journal of Microelectromechanical Systems, Sensors and Actuators B, Biosensors and Bioelectronics, Nanoscience and Nanotechnology Letters, Sensors and Transducers, and Journal of Micromechanics and Micromachining.

Course certificate

• The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
• The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
• Date and Time of Exams: 26th April 2020, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
• Registration url: Announcements will be made when the registration form is open for registrations.
• The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
• Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE:
• Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
• Exam score = 75% of the proctored certification exam score out of 100
• Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75.
• If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
• Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IISc Bangalore. It will be e-verifiable at nptel.ac.in/noc.
• Only the e-certificate will be made available. Hard copies will not be dispatched.

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