Industrial Pharmacy I

By Dr. Ajay Semalty | H.N.B Garhwal University (A Central University) Srinagar Garhwal

Learners enrolled: 2299

The course is one of the paper of Fifth semester of B. Pharmacy syllabi approved by Pharmacy council of India (PCI) and is adopted uniformly by all the pharmacy institutions and Universities throughout the country. All other learners who want to learn the basics of industrial pharmacy can get the vital benefit out of this course.

Objectives:

The course has been designed with the aim that after completing this course you should be able

1. To understand Dosage forms and their manufacturing techniques

2. To understand all the related and practical aspect of dosage form development.

4. To formulate and evaluate solid, liquid and semisolid dosage forms

5. To correlate the theoretical knowledge with professional and practical need of Pharmaceutical industry.

Target Learners:

The course is beneficial for teachers, students and the industry personals. The pharmacy faculty members if enroll and complete this course will earn the benefit of refreshing and updating their knowledge. Students will get the 4 credits. And the industry personals who are not from pharmacy background may enrich their knowledge with this course.

Course has been designed with the USPs: easy language, to-the-point coverage of topics, pictorial/graphical, animated and Audio Video knowledge store with the standards needed by the Pharma industry. The course is one of the pioneer MOOC in pharmaceutical sciences developed with the expert advice from academia (Prof. Y. S. Tanwar, B.N. University Udaipur) and industry experts (Mr Soumaya Dutt, G.M. –Mfg. and Site Head Formulation and Operation, Glennmark Pharma. Ltd. Sikkim).

The Team IP

Dr Ajay Semalty (Course Coordinator & Subject Matter Expert)
Dr Mona Semalty (Co-Course Coordinator & Subject Matter Expert)
Mr Lokesh Adhikari (Subject Matter Expert)

Production: EMRC Roorkee

Summary

Course Status :	Completed
Course Type :	Core
Duration :	12 weeks
Category :	Multidisciplinary
Credit Points :	4
Level :	Undergraduate
Start Date :	22 Jul 2019
End Date :	21 Oct 2019
Enrollment Ends :	07 Sep 2019
Exam Date :	10 Nov 2019 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1 Preformulation I

Preformulation I: Physical form (crystal & amorphous),

Preformulation I: polymorphism, particle size, shape

Preformulation I:, solubility profile (pKa, pH, ,

Preformulation I: partition coefficient, flow properties),

Week 2 Preformulation II

Preformulation II: Hydrolysis, oxidation, reduction

Preformulation II: Racemisation,

Preformulation II: Dissolution, permeability & BCS classification

Preformulation II: Polymerization

Week 3 Tablets

Tablets: Introduction, classification of tablets. Formulation/preparing of tablets, granulation methods.

Tablets: Compression and processing problems. Equipment and tablet tooling, Tablet defects.

Tablets: Tablet coating: Types, coating materials, formulation of coating composition, methods of coating, equipments employed and defects in coating

Tablets: QC of tablets: apparatus, methods, graphical presentations, official and unofficial tests.

Week 4 Liquid Orals:

Liquid orals: Formulation and manufacturing of solution, syrups and elixirs, Filling and packaging

Liquid orals: Emulsions: I

Liquid orals: Emulsion II

Liquid orals: Suspensions: Formulation, evaluation

Week 5 Parenterals I

Parenterals I: Introduction, Preformulation of parenterals

Parenterals I: Formulation of Parenterals

Week 6 Parenterals I

Parenterals I: Types of Parenteral preparation

Parenterals I: Lay out and Production facilities

Week 7 Parenterals II

Parenterals II: Pyrogens and pyrogenisity

Parenterals II: Quality control of parenterals

Week 8 Capsules:

Capsules: Introduction, Advantages, Disadvantages, Capsule Production, hard Gelatin capsules

Capsules: Methods of filling capsules, Soft Gelatin Capsules

Capsules: Formulation Consideration, Production of soft gelatin capsules, Non-gelatin soft capsules

Capsules: Evaluation of commercial capsules

Week 9 Pellets and Ophthalmic Preparations:

Pellets: Introduction, formulation, pelletization process, equipment needed

Ophthalmic Preparations: Introduction, absorption through eye, formulation considerations

Ophthalmic Preparations: formulation of eye drops, lotion, ointments

Ophthalmic Preparations: Methods of preparation; labeling, containers Evaluation

Week 10 Pharmaceutical Aerosols:

Pharmaceutical Aerosols: Definitions, Advantages, Limitation, Uses

Pharmaceutical Aerosols: Components of aerosols

Pharmaceutical Aerosols: Components and systems of aerosols

Pharmaceutical Aerosols: inhalers and Evaluation of Aerosols

Week 11 Cosmetics:

Cosmetics: Introduction, absorption through skin, types of cosmetic preparations, Formulation of tooth pastes

Cosmetics: Formulation of lipsticks, shampoos, hair dyes

Cosmetics: Formulation of cold cream and vanishing cream, sunscreens

Week 12 Packaging Materials Science:

Packaging Materials Science: Materials used for packaging of pharmaceutical products,

Packaging Materials Science: Factors influencing choice of containers Legal and official requirements, Stability aspects,

Packaging Materials Science: Quality control tests of packaging materials

Books and references

1. IP/USP/BP

2. Niazi SK, Handbook of Preformulation, Informa Health Care, 2007

3. Aulton ME (ED), Pharmaceutics: The science of Dosage form design, II edn, Churchill Livingstone, London, 2002.

4. Banker GS & Rhodes T, Modern Pharmaceutics, CRC Press.

5. Lachman L/Lieberman HA, Kanig JL, The Theory And Practice Of Industrial Pharmacy,4E (2013).

6. Qiu Y, Chang Y and Zhang GZ (Exe. Eds), Developing solid oral dosage forms: Pharmaceutical theory and
practice,Elsevier,2009

7. Gibson M. (Ed), Pharmaceutical preformulation and formulation: a practical guide from candidate drug selection to
commerciai dosage form, II edn, Informa Healthcare.

8. Qiu Y, Chang Y and Zhang GZ (Exe. Eds), Developing solid oral dosage forms: Pharmaceutical theory and practice, Elsevier,
2009

9. Dressman JB, Karmer J, Pharmaceutical Dissolution Testing, 2005, Taylor and Francis, New York.

10.Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. Philadelphia: Lipincott Williams and Wilkins.

11. Semalty et al. Essentials of Pharmaceutical Technology, II edn, 2018, Pharma med Press, Hyderabad

12. Augsburger LL, Hoag SW (Eds), Pharmaceutical Dosage Forms: Tablets, Volume 1, III Edn, Informa healthcare, 2008

Instructor bio

Dr. Ajay Semalty, is Assistant Professor (Pharmaceutics), in Department of Pharmaceutical Sciences, H.N.B. Garhwal University (A Central University) Srinagar (Garhwal), Uttarakhand.

M. Pharm. (Pharmaceutics), MBA (Operations Management); Ph. D., PDF Meijo University, Japan; Academic and research experience of 15.5 Yrs with 1 yr Industrial Experience; Completed 8 research projects funded by various agencies; Published 73 papers, 6 books, 2 patents (01 granted). Presented papers in more than 100 conferences; Highly cited researcher of the field (h index 22); Awarded Daiko Foundation Post-Doctoral Research Fellowship and invited by Meijo University, Nagoya, Japan as visiting scientist for research for FY 2011-12; Awarded with the prestigious national Research Award (Pharmacy) by UGC, New Delhi and Young Scientist Award of the year 2007 by Uttarakhand Council of Science & Technology (UCOST); Expert reviewer of Iceland Research Foundation Iceland; Israel Research Foundation Israel and Scientific Expert (REPRISE) for Ministry of Institution and University Research (MIUR), Italy; Delivered invited lectures on OER, Plagiarism, MOOCs, nanotechnology etc. Member of The Asian Council of Science Editors, APTI and IPA; Editorial Board Member and Peer reviewer of various national and International reputed journals; The University SWAYAM Coordinator of Garhwal University; Supervised 20 M. Pharm research projects; Research interest include cyclodextrin and lipid complexes, Small angle neutron scattering (SANS), nanoparticles, natural products for drug delivery like obesity and hair loss.