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Swayam Central

Microbial Physiology and metabolism

By Dr. RAGHAVENDRA M.P.   |   Maharani’s Science College for Women, Mysuru-570 005
Microbial physiology and metabolism provides information on sources of energy and its utilization by microorganisms. Microorganisms play important role in environment as producers, consumers and decomposers. These are the only group of organisms which takes part in all three important stages of ecosystem. Understanding microbial physiology has greater application in industry, developing medicine and even in agriculture. Microorganisms being Lilliput in size behaves like tiny factories to produce several enzymes, metabolites of industrial importance which are regulated by specific genes under the influence of environmental factors. Regulating these two parameters will provide greater output of the metabolites of the choice. To know the specific parameters it is important to understand physiology of these organisms in detail.

Microorganisms are also very special considering its ability to degrade different carbon sources and converting them both aerobically and anaerobically to metabolites of commercial value. This diverse metabolic activity is generally not observed in any other group of living organisms.The syllabus of the course is designed keeping in mind the recent developments in microbial physiology and will be useful to all those who want to learn and update their knowledge on physiology of microorganisms.


Learners enrolled: 579

SUMMARY

Course Status : Upcoming
Course Type : Elective
Duration : 12 weeks
Start Date : 06 Jul 2020
End Date : 29 Nov 2020
Exam Date :
Enrollment Ends : 30 Sep 2020
Category :
  • Biological Sciences & Bioengineering
  • Level : Undergraduate

    COURSE LAYOUT


    Weeks

    Day

    Weekly Lecture Topics

    First Week

    Day 1

    Microbial enzymes: Structure and Classification

    Day 2

    Mechanism of Enzyme actions: Lock and key model, induced fit theory

    Day 3

    Factors affecting rates of enzyme mediated reactions

    Day 4

    The role of ATP in metabolism

    Day 5

    ●       MCQ

    ●       Assignments

     

    Second Week

    Day 1

    Definitions of growth and generation time, measurement of microbial growth and specific growth rate

    Day 2

    Batch and Continuous culture

    Day 3

    Phases and types of growth curve and its industrial application

    Day 4

    Microbial growth in response to temperature,  pH, solute and water activity, oxygen, pressure and radiation

    Day 5

    ●       MCQ

    ●       Assignments

     

    Third Week

    Day 1

    Classification of bacteria based on nutrients

    Day 2

    Membranes of microorganisms, Ion channels

    Day 3

    Passive and facilitated diffusion, Primary and secondary active transport, concept of uniport, symport and antiport

    Day 4

    Group translocation and Iron uptake

    Day 5

    ●       MCQ

    ●       Assignments

     

    Fourth Week

    Day 1

    Photosynthetic pigments and apparatus in bacteria

    Day 2

    Photophosphorylation

    Day 3

    C3 and C4 pathways

    Day 4

    Difference between oxygenic and anoxygenic photosynthesis

    Day 5

    ●       MCQ

    ●       Assignments

    Fifth Week

    Day 1

    Mode of nutrition in Hydrogen and Nitrifying bacteria

    Day 2

    Mode of nutrition in Purple sulfur bacteria, Non-sulfur bacteria and Green sulfur bacteria

    Day 3

    Mode of nutrition in methylotrophs and methanogens

    Day 4

    Utilization of light energy by halobacteria

    Day 5

    ●       MCQ

    ●       Assignments

    Sixth  Week

    Day 1

    Concept of aerobic respiration, anaerobic respiration and fermentation

    Day 2

    Sugar degradation pathways i.e., EMP, ED and Pentose phosphate pathway

    Day 3

    TCA cycle and Electron transport chain

    Day 4

    Comparison of mitochondrial and bacterial ETC, electron transport phosphorylation, uncouplers and inhibitors

    Day 5

    ●       MCQ

    ●       Assignments

     

    Seventh  Week

    Day 1

    Fates of pyruvate, Pasteur effect and industrial importance of fermentation

    Day 2

    Alcohol fermentation

    Day 3

    Lactate fermentation (homo fermentative and hetero fermentative pathways)

    Day 4

    Concept of linear and branched fermentation pathways

    Day 5

    ●       Quizzes

    ●       Assignments

    ●       Paragraph and essay questions

     

    Eighth Week

    Day 1

    Utilization of Lactose and Galactose

    Day 2

    Utilization of Maltose and Mannitol

    Day 3

    Degradation of cellulose, starch and glycogen

    Day 4

    Conversion of biomass to energy using microorganisms

    Day 5

    ●       MCQ

    ●       Assignments

     

    Ninth  Week

    Day 1

    Mechanism of nitrogen fixation

    Day 2

    Symbiotic and non symbiotic nitrogen fixation

    Day 3

    Biosynthesis of amino acids

    Day 4

    Degradation amino acids

    Day 5

    ●       MCQ

    ●       Assignments

    Tenth Week

    Day 1

    Oxidative stress

    Day 2

    Thermal stress

    Day 3

    Starvation stress and stringent response

    Day 4

    Aerobic to anaerobic transitions

    Day 5

    ●       MCQ

    ●       Assignments

     

    Eleventh   Week

    Day 1

    Exam preparation and assessment of assignments

    Day 2

    Day 3

    Day 4

    Day 5

    Twelfth   Week

    Day 1

    Assessment at the end of the course, which comprises of 40% of Online or In-term assessment and 60% Proctored end term exam.

    Day 2

    Day 3

    Day 4

    Day 5

     

    BOOKS AND REFERENCES

    1.   Moat A.G., Foster J.W. and Spector M.P. 2002. Microbial Physiology, 4th edition. A Johan Wiley and sons inc., publication.


    2.  Kim B.H. and Gadd G.M. 2008. Bacterial physiology and metabolism. Cambridge University Press, Cambridge.


    3.  Gilbert H.F. 2000. Basic concepts in biochemistry: A student’s survival guide. Second Edition. Mc-Graw-Hill Companies, health professions Division, New York.


    4.  Madigan M.T., Martinko J.M., Stahl D.A. and Calrk D.P. 2012. Brock Biology of Microorganisms. 13th ed. Pearson Education Inc.


    INSTRUCTOR BIO

    Dr. RAGHAVENDRA M.P.

    Maharani’s Science College for Women, Mysuru-570 005
    Dr. Raghavendra M.P. is presently working as a Assistant Professor in PG Department of Microbiology, Maharani’s Science College for Women, Mysuru. He obtained M.Sc. and Ph.D. in Microbiology from University of Mysore during 1999 and 2007 respectively. He has cleared CSIR-UGC-NET in life sciences (2001), ICMR-JRF competitive exam in 2000 and recipient of CSIR-SRF during 2003-2006. He is a recipient of ISCA young scientist award in 2010 and Dr. Anne Kuriakose endowment best teacher in India award in 2016 with cash prize Rs. 10,000=00. He has published 40 research papers with 1150 citations, with an h index of 15 and i10 index of 18. He has authored 15 book chapters published by CABI, Springer, Elsevier and other publishers. He has more than 16 years of teaching experience at postgraduate level.

    COURSE CERTIFICATE

    Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

    End Term Exam- will have 100 questions and will carry 70 percent of  overall Result.

    *All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.

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