Swayam Central

Organic Chemistry 1

By Dr. B. S. Balaji   |   Jawaharlal Nehru University

Number of Credits =4

This course is a 4 credit course (15 weeks, 40 module) for M. Sc. Chemistry Students. Here, Students will be trained to improve their factual, conceptual, procedural and metacognitive knowledge. The scientific explanation given in the video contents makes use of the following components: Presentations, chemical structures, figures, tables, images, 3D-animations, white board demonstration, use of molecular models, paper 3D-models, mirrors etc. We gave emphasis to instructional design by leveraging theories based on Malcom  Knowels Andragogy, modified Bloom’s taxonomy, the Feynman Technique, ADDIE model, Dick and Carey model, neuro slide design principles etc. 

Learners enrolled: 3224


Course Status : Ongoing
Course Type : Core
Duration : 15 weeks
Start Date : 06 Jan 2020
End Date : 18 Apr 2020
Exam Date : 09 May 2020
Enrollment Ends : 08 Mar 2020
Category :
  • Chemical Engineering
  • Chemistry
  • Level : Postgraduate


    Learner's Feedback:

    "This course is very great and is helpful not only for students but also for all chemistry professors. This course is the best platform for all organic chemistry learners. The language is very easy. So that, each and every student can understand all the concepts easily. Discussion forum is also a best platform for us to ask any query about any concept.
    Thank you very much sir for excellent teaching, clearing every concept in organic chemistry from basic and giving assignments to us. Keep it up sir.
    Also,thanks to SWAYAM for conducting such type of course for all chemistry learners." ---- Ketaki, One of the topper from the course July-2019.

     "The classes are very explanatory and very useful for the PG students and also for the faculty members. I really appreciate the efforts taken by Balaji sir. " ---Seethalakshmi S
    "The course content was so relevant and insightful that every individual would definitely benefit hugely from it for their career in chemistry. The classes are very vivid, crystal clear and knowledgeable. I am very fortunate to be part of this course." ---- Ramakrishna S "Professor Balaji did splendid job and did lots of efforts. Its been 15 days to the course have started and I am taking it right now. This course is beneficial to all as the professor took the course from basics to advance, this make learning very easy & he is very responsive which makes it very convenient." ----- Simran K "very good nd well qualified professors.
    for solving gate, net questions, dis course iz useful. thanku for efforts of all professors". ---- Anonymous
    Syllabus Week 1 

    Introduction to stereochemistry Conformational analysis of open chain systems

    Week 2 

    Conformational analysis of cyclic systems Symmetry elements, Point group analysis Stereochemical conventions 

    Week 3 

    Stereogenicity, Topicity ORD and CD, Axial halo ketone rule, Octant Rule

    Week 4

    Stereochemical reactions Reactions involving stereo centres Crams Rule, Felkin-Anh model, Prelog rules

    Week 5

    Aromaticity, Aromatic stabilization energy, Hückel MO, Musulin-Frost diagram Polycyclic aromatic hydrocarbon (PAH), Polyacenes, Annulene

    Week 6 

    Aromatic Electrophilic substitutions Aromatic Nucleophilic substitutions Ipso-cine-tele substitution

    Week 7

    Reaction dynamics, Hammond postulate Linear free energy relationship, Hammett equation

    Week 8

    Yukawa Tsuno equation, Swain-Lupton equation, Grunwald–Winstein equation, Taft equation Curtin-Hammett principle, Winstein-Holness equation 

    Carbocation, Part 1: Generation, Structure and Geometry

    Week 9

    Carbocation, Part 2: Stabilisation of carbocation, Reactions

    Carbocation, Rearrangement 1: No Change in carbon skeleton, Change in carbon skeleton 

    Carbocation, Rearrangement 2: involvement of other electron deficient terminus, Anchimeric assistance

    Week 10

    Carbanions: pKa and its significance

    Carbanions: Hard and Soft Acid and Base principle

    Carbanions: Structure, Formation, Stability, Reactivity

    Week 11

    Carbanion reactions: Acyl Anions, Benzoin condensation, Umpolung-inversion of reactivity

    Free radical 1: Formation, Structure, Stability

    Week 12

    Free radical 2: Stability, Reactivity Free radical 3: Reactions: Addition, atom abstraction, disproportionation, cyclisation

    Week 13

    Free radical 4: Reactions: Fenton, Kolbe, Bouveault-Blanc, Giese, Hofmann-Loffler, Birch, Barton-McCombie, Sandmeyer, Barton decarboxylation Carbene, Nitrene: Generation, Structure, Reactivity

    Week 14

    Carbonyl addition reaction Enol and enolate formation and reactions

    Enamines formation and reactions

    Week 15

    Enol ethers formation and reactions, Mukaiyama-Aldol reaction Sharpless epoxidation, Click reaction, Diels-Alder reaction- Scope and mechanism



    March's Advanced Organic Chemistry Reactions, Mechanisms and Structure 5th Ed. Michael B. Smith, Jerry March, John Wiley & Sons, Inc., 2001.

    F. A. Carey: Organic Chemistry, 5th  Ed., McGraw-Hill, 2004.

    Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, 6th Ed, John Wiley and Sons. Inc, New York, 1986.

    J. Clayden, N. Greeves, S. Warren, Organic Chemistry, 2nd Ed., Oxford University Press, New Delhi, 2012.

    F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A & B, 5th  Ed., Springer, New York, 2007.

    Thomas H. Lowry and Kathleen Schueller Richardson, Mechanism and theory in Organic Chemistry, Harper& Row, Publishers, 1976.

    Paula Yurkanis Bruice, Organic Chemistry, 4th Ed. Prentice Hall, 2003.

    Arvi Rauk, Orbital Interaction Theory of Organic Chemistry, 2nd Ed., John Wiley & Sons, Inc., 2001.

    D. Nasipuri, Stereochemistry of organic compounds, Principles and Applications, 3rd Ed. New Age International Publishers, 2018.

    P. S. Kalsi, Stereochemistry: Conformation and Mechanism, 9th Ed, New Age International (P) Ltd., 2017.

    Ernest L. Eliel, Samuel H. Wilen, Stereochemistry of Organic Compounds, Wiley India Ed, 2008.

    I. L. Finar, Organic Chemistry, Volume 2: Stereochemistry and The Chemistry of Natural Products, Chapter 2, 5th Ed, Pearson Education India, 1956.


    Dr. B. S. Balaji

    Jawaharlal Nehru University
    Currently Dr. Balaji is serving as subject matter expert/external Academic consultant to e-VidyaBharati/ ArogyaBharati project of Ministry of External affairs, Government of India in collaboration with National Institute for Smart Governance. 
    Dr. Balaji is working as Associate Professor at School of Biotechnology, Jawaharlal Nehru University. His area of specialization includes Green chemistry, synthetic chemistry, drug development, nano-chemistry, teaching and learning methodologies. He received his Ph.D in organic Chemistry from National Chemical Laboratory, Pune, affiliated to then Pune University. He spent three years as Center of Excellence Foreign Visiting researcher at Hokkaido University, Sapporo, Japan. He then worked as Postdoctoral fellow and Research fellow (faculty track position) at University of Missouri, Columbia, USA for five years. He had published 18 research publications (including a book) and holds four Indian patents. The research contribution from his laboratory had appeared in few Journal cover pages (Chemical Communication, Nuclear Medicine and Biology) and appeared in local print and electronic media. He got his MBA from Anna University with Technology management as specialization.


    “30 Marks will be allocated for Internal Assessment and 70 Marks will be allocated for external proctored examination”

    There will be weekly graded evaluation. To get a certificate, you have to attempt weekly graded crossword puzzle 30% weight (best 6 out of 15 graded puzzle) and final proctored examination 70% weight.

    Best of 6 out of 15 graded quizzes/crossword puzzles will be considered for internal evaluation. The selection of 6 best quizzes will be spread over the entire 15 weeks. We will select 2 best quizzes from Week 1 to 5, another two from Week 6-10 and last two from Week 11-15.