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Thank you very much sir for excellent teaching, clearing every concept in organic chemistry from basic and giving assignments to us. Keep it up sir.
Also,thanks to SWAYAM for conducting such type of course for all chemistry learners." ---- Ketaki, One of the topper from the course July-2019.
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Syllabus
Week 1
Introduction to stereochemistry
Conformational analysis of open chain systems
Week 2
Conformational analysis of cyclic systems Symmetry elements, Point group analysis Stereochemical conventions
Week 3
Stereogenicity, Topicity ORD and CD, Axial halo ketone rule, Octant Rule
Week 4
Stereochemical reactions Reactions involving stereo centres Crams Rule, Felkin-Anh model, Prelog rules
Week 5
Aromaticity, Aromatic stabilization energy, Hückel MO, Musulin-Frost diagram Polycyclic aromatic hydrocarbon (PAH), Polyacenes, Annulene
Week 6
Aromatic Electrophilic substitutions Aromatic Nucleophilic substitutions Ipso-cine-tele substitution
Week 7
Reaction dynamics, Hammond postulate Linear free energy relationship, Hammett equation
Week 8
Yukawa Tsuno equation, Swain-Lupton equation, Grunwald–Winstein equation, Taft equation Curtin-Hammett principle, Winstein-Holness equation
Carbocation, Part 1: Generation, Structure and Geometry
Week 9
Carbocation, Part 2: Stabilisation of carbocation, Reactions
Carbocation, Rearrangement 1: No Change in carbon skeleton, Change in carbon skeleton
Carbocation, Rearrangement 2: involvement of other electron deficient terminus, Anchimeric assistance
Week 10
Carbanions: pKa and its significance
Carbanions: Hard and Soft Acid and Base principle
Carbanions: Structure, Formation, Stability, Reactivity
Week 11
Carbanion reactions: Acyl Anions, Benzoin condensation, Umpolung-inversion of reactivity
Free radical 1: Formation, Structure, Stability
Week 12
Free radical 2: Stability, Reactivity Free radical 3: Reactions: Addition, atom abstraction, disproportionation, cyclisation
Week 13
Free radical 4: Reactions: Fenton, Kolbe, Bouveault-Blanc, Giese, Hofmann-Loffler, Birch, Barton-McCombie, Sandmeyer, Barton decarboxylation
Carbene, Nitrene: Generation, Structure, Reactivity
Week 14
Carbonyl addition reaction Enol and enolate formation and reactions
Enamines formation and reactionsWeek 15
Enol ethers formation and reactions, Mukaiyama-Aldol reaction Sharpless epoxidation, Click reaction, Diels-Alder reaction- Scope and mechanism
Exam
March's Advanced Organic Chemistry Reactions, Mechanisms and Structure 5th Ed. Michael B. Smith, Jerry March, John Wiley & Sons, Inc., 2001.
F. A. Carey: Organic Chemistry, 5th Ed., McGraw-Hill, 2004.
Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, 6th Ed, John Wiley and Sons. Inc, New York, 1986.
J. Clayden, N. Greeves, S. Warren, Organic Chemistry, 2nd Ed., Oxford University Press, New Delhi, 2012.
F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A & B, 5th Ed., Springer, New York, 2007.
Thomas H. Lowry and Kathleen Schueller Richardson, Mechanism and theory in Organic Chemistry, Harper& Row, Publishers, 1976.
Paula Yurkanis Bruice, Organic Chemistry, 4th Ed. Prentice Hall, 2003.
Arvi Rauk, Orbital Interaction Theory of Organic Chemistry, 2nd Ed., John Wiley & Sons, Inc., 2001.
D. Nasipuri, Stereochemistry of organic compounds, Principles and Applications, 3rd Ed. New Age International Publishers, 2018.
P. S. Kalsi, Stereochemistry: Conformation and Mechanism, 9th Ed, New Age International (P) Ltd., 2017.
Ernest L. Eliel, Samuel H. Wilen, Stereochemistry of Organic Compounds, Wiley India Ed, 2008.
I. L. Finar, Organic Chemistry, Volume 2: Stereochemistry and The Chemistry of Natural Products, Chapter 2, 5th Ed, Pearson Education India, 1956.
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