Metals In Biology

By Dr. Debabrata Maiti | IIT Bombay

Learners enrolled: 753

Metals are the vital component of any biosystem. Starting from transporting biochemicals to catalyzing biochemical transformations, almost every process requires presence of a metal center. In order to understand these processes knowledge of specific functions carried out by these metals are necessary. This course will be helpful to understand the fundamental properties of the metals present in biosystems and mechanism of their action.

INTENDED AUDIENCE : Chemistry, Biochemistry Students/faculty

PREREQUISITES : Nil

Summary

Course Status :	Completed
Course Type :	Core
Duration :	8 weeks
Category :	Chemistry
Credit Points :	2
Level :	Postgraduate
Start Date :	29 Jul 2019
End Date :	20 Sep 2019
Exam Date :	29 Sep 2019 IST

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1 :
Lecture 1: Introduction
Lecture 2,3: Distribution of metals in biology
Lecture 4,5: Metal storage in body
Week 2 :

Lecture 6,7: Regulation of metal ion concentrations
Lecture 8,9 : Hydrolytic enzymes-Carbonic anhydrase & carbopeptidase
Lecture 10: Hydrolytic enzymes-Araginase and urease

Week 3 :
Lecture 11: Oxygen transport proteins
Lecture 12,13,14: Dioxygen reactivity in copper
Lecture 15: Copper-oxygen chemistry

Week 4 :
Lecture 16: Copper-oxygen chemistry and its mechanism
Lecture 17,18: Iron catalyzed oxidation
Lecture 19,20: Nitrous oxide reductase

Week 5 :
Lecture 21,22: Cytochrome C oxidase
Lecture 23: Mononuclear nonheme iron (NHI) enzymes
Lecture 24: alpha-Keto Glutarate dependent Halogenase
Lecture 25: Cytochrome P450-Introduction

Week 6 :
Lecture 26: Cytochrome P450-Part II-Reactions
Lecture 27,28: Cytochrome P450-Part III- Mechanism & Role of Cysteine ligand
Lecture 29,30: Methane monooxygenase

Week 7 :
Lecture 31,32: Photosynthesis
Lecture 33,34: Photosynthesis & pumps - channels
Lecture 35: Protein involved in O2 transport

Week 8 :
Lecture 36: Dioxygen reactivity in copper
Lecture 37,38: Dioxygen reactivity in iron

Books and references

Principles of Bioinorganic Chemistry- Stephen J. Lippard

Instructor bio

I am Dr. Debabrata Maiti, Associate Professor at IIT Bombay. I have completed my PhD from Johns Hopkins University with Prof. Kenneth D. Karlin in bioinorganic chemistry. Then I moved to MIT where I did my Post-doctoral research with Prof. Steven Buchwald. I have started independent carrier at IIT Bombay in 2011 and since then involved actively in teaching bio-inorganic chemistry and organometallic chemistry. Our group is also active in research areas of bio-inorganic chemistry and C-H activation.

Course certificate

The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 29th September 2019 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given in the course.
Exam score = 75% of the proctored certification exam score out of 100
Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75.

If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Bombay. It will be e-verifiable at nptel.ac.in/noc.
Only the e-certificate will be made available. Hard copies are being discontinued from July 2019 semester and will not be dispatched

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