Swayam Central

Quantitative Methods in Chemistry

By Prof. Aasheesh , Prof. Bharathwaj Sathyamoorthy   |   IISER Bhopal
This course aims to train students towards appropriate scientific reporting of the experimental data and testing hypothesis using statistical analyses. It emphasizes on reproducibility of experiments and the sources of “errors” during repetitions of experiments, how to quantify and minimize wherever feasible. In the later part, it deals with the principles of volumetric analysis, separation techniques (for instance chromatography, gravimetric analysis, etc.) employed for chemicals and biomolecules. Principles of instrumentation techniques will also be discussed.
INTENDED AUDIENCE : 3rd year B.Sc./3rd year BS-MS
PREREQUISITES : Basic Chemistry courses, basic mathematics from school 10+2 standard
INDUSTRY SUPPORT : Not approached yet, in the process.

Learners enrolled: 287


Course Status : Upcoming
Course Type : Elective
Duration : 12 weeks
Start Date : 27 Jan 2020
End Date : 17 Apr 2020
Exam Date : 26 Apr 2020
Enrollment Ends : 03 Feb 2020
Category :
  • Chemistry
  • Level : Undergraduate
    This is an AICTE approved FDP course


    Week 1: Chemical stoichiometry, parameters to define concentration of chemicals (normality, molarity, molality, mole-fractions, parts-per million), analytical concentration and equilibrium concentrations, p-value of concentration Week 2: Measurements and its statistical analyses (definition of mean, median, mode, variance, standard deviation, standard error, accuracy, precision), need for performing replicates/repeats,reproducibility Week 3: Classification and sources of errors, error propagation, scientific reporting data (significant figures), error curves Week 4: Hypothesis validation (null hypothesis, confidence levels, confidence intervals, one-tail test, two-tail test, use of statistical tables such as z-table, t-table, F-table, identifying outliers in data with Q-test) Week 5: Sampling, fitting and analysis of data (linear regression, single factor analysis of variance, least-significant difference). Week 6: Software-based data analysis (linear and non-linear regression) Week 7: Examples of data fitting and analysis (application to rate kinetics, gradient mixing, biomolecular folding) Week 8: Sample preparation: concept of standards (primary and secondary), traditional methods of analysis (gravimetric, volumetric, potentiometric methods) Week 9: Analytical separations (solvent extraction, chemical precipitation, chromatography, types of chromatography – size exclusion, ion exchange, affinity, gas, high pressure liquid chromatography, field-flow fractionation) Week 10: Theoretical basis of chromatography (concept of plates, theoretical plate height, plate count, resolution, retention time, retention factor, selectivity factor) Week 11: Differences between rate theory and plate theory Week 12: Protocols with video demonstration of separation techniques


    1. Skoog, D. A. et al., Fundamentals of Analytical Chemistry, 9th Ed., Cengage Learning, 2013. 2. Christian, G.D., Analytical Chemistry, 6th Ed., Wiley, 2003 3. Gordus, A. A., Schaum’s Outline of Analytical Chemistry, 1st Ed., Tata-McGraw Hill, 1985


    Prof. Aasheesh

    IISER Bhopal
    Dr. Aasheesh Srivastava is currently the Head, Department of Chemistry, IISER Bhopal. He secured his Ph.D. in the field of Bio-organic Chemistry and has experience in the research of bio-inspired materials during his postdoctoral stint. Following his appointment as an Assistant Professor in IISER Bhopal in 2009, he has been teaching under- and post-graduate students and pursuing independent research in the fields of soft nanomaterials, bio-degradable polymers and drug delivery.

    Prof. Bharathwaj Sathyamoorthy

    Dr. Bharathwaj Sathyamoorthy secured his Ph.D. in the field of Bio-physical Chemistry and is a solution-state Nuclear Magnetic Resonance (NMR) spectroscopist by training. Following his appointment as an Assistant Professor in IISER Bhopal in 2015, he has been teaching under- and post-graduate students and pursuing independent research studying the structure and dynamics of biomolecules employing NMR.


    • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
    • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
    Date and Time of Exams:
    26th April 2020, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
    • Registration url: Announcements will be made when the registration form is open for registrations.
    • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
    • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.


    • Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
    • Exam score = 75% of the proctored certification exam score out of 100
    • Final score = Average assignment score + Exam score

    • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
    • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Madras. It will be e-verifiable at nptel.ac.in/noc.
    • Only the e-certificate will be made available. Hard copies will not be dispatched.