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Swayam Central

Essentials of Biomolecules: Nucleic Acids and Peptides

By Prof. Lal Mohan Kundu   |   IIT Guwahati
The proposed course aims to provide essentials of chemistry and biology of two very important class of biomolecules: nucleic acids (DNA/RNA) and proteins. The course allows to decipher: how structural features are translated into biological functions; how highly organized and selective chemical reactions are adopted that allows DNA to replicate or dictates step-wise synthesis of specific sequence of proteins; how organic chemistry tools in combination with enzymes were ingeniously applied to determine sequences of DNA and proteins and how chemical modifications could be done to mimic similar biological properties. The course also includes modern techniques, development of biomolecular probes as high-throughput detection of biomolecules, single nucleotide polymorphisms and disease diagnosis. Overall, the course falls within the domain of organic chemistry and chemical biology.


INTENDED AUDIENCE : For chemistry, Biochemistry and Biotechnology students
PREREQUISITES : Basic knowledge in organic chemistry
INDUSTRY SUPPORT : All major pharmaceuticals and Biotech companies

Learners enrolled: 299

SUMMARY

Course Status : Upcoming
Course Type : Core
Duration : 12 weeks
Start Date : 27 Jan 2020
End Date : 17 Apr 2020
Exam Date : 26 Apr 2020
Enrollment Ends : 03 Feb 2020
Category :
  • Chemistry
  • Level : Postgraduate
    This is an AICTE approved FDP course

    COURSE LAYOUT

    Week  1: Introduction, Nucleic acids and proteins
    Week  2: Synthesis of nucleobases, nucleotides and oligonucleotides
    Week  3: Solid phase synthesis of oligonucleotides
    Week  4: DNA replication, Polymerases, DNA sequencing and PCR
    Week  5: DNA damage, mutations and cancer
    Week  6: DNA to proteins: transcription, translation and genetic code
    Week  7: Peptides, sequencing and applications in therapeutics
    Week  8: Solution phase and solid phase peptide synthesis
    Week  9: Expansion of genetic code: PNA, LNA and molecular probes
    Week 10: Modern techniques for biomolecules and disease diagnosis
    Week 11: Structures and chemistry of sugars and carbohydrates
    Week 12: Carbohydrate based polymers as biomolecular probes and therapeutics; conclusion

    BOOKS AND REFERENCES

    1. Essentials of Chemical Biology by A. Miller and J. Tanner
    2. Biochemistry by Berg,Tymoczkao and Stryer

    INSTRUCTOR BIO

    Prof. Lal Mohan Kundu

    IIT Guwahati
    Dr. Lal Mohan Kundu studied B.Sc. (Honors) in chemistry from RKMRC Narendrapur, Calcutta University in 1998. After completing master degree in chemistry from IIT Kharagpur in 2000, he moved to LMU Munich, Germany to pursue PhD with Prof. Thomas Carell. During this tenure he worked for the development of modified nucleic acids, DNA damage and repair. During postdoctoral stay at University of Alberta, Canada with Prof. Glan Loppnow and subsequently with Prof. Mizuo Maeda in RIKEN, Japan, he worked for the synthesis of modified nucleic acids probes for high-throughput detection of genomic mutations. Dr. Kundu joined the department of chemistry at IIT Guwahati in 2009 as assistant professor. Hes currently as associate professor and works in organic synthesis of nucleic acids, anticancer agents, peptide chemistry, biomolecular based targeted drug delivery and nanoparticle based therapeutics. His teachings in UG and PG level include: organic chemistry, chemical biology, biological macromolecules

    COURSE CERTIFICATE

    • The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam conducted by us in person at any of the designated exam centres.
    • The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
    Date and Time of Exams: 26th April 2020, Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
    • Registration url: Announcements will be made when the registration form is open for registrations.
    • The online registration form has to be filled and the certification exam fee needs to be paid. More details will be made available when the exam registration form is published. If there are any changes, it will be mentioned then.
    • Please check the form for more details on the cities where the exams will be held, the conditions you agree to when you fill the form etc.

    CRITERIA TO GET A CERTIFICATE:
    • Average assignment score = 25% of average of best 8 assignments out of the total 12 assignments given in the course.
    • Exam score = 75% of the proctored certification exam score out of 100
    • Final score = Average assignment score + Exam score

    YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25 AND EXAM SCORE >= 30/75.
    • If one of the 2 criteria is not met, you will not get the certificate even if the Final score >= 40/100.
    • Certificate will have your name, photograph and the score in the final exam with the breakup.It will have the logos of NPTEL and IIT Guwahati. It will be e-verifiable at nptel.ac.in/noc.
    • Only the e-certificate will be made available. Hard copies will not be dispatched.

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