Immunology

By Dr. Reena Haobam | Department of Biotechnology, Manipur University

Learners enrolled: 2211

Immunology is the study of the immune system. The immune system is the body’s own defence mechanism to protect from various harmful microbial infections. A basic course in immunology is important for those students who opt for undergraduate and post graduate courses in biological sciences. The course focus on understanding basic immunology, and also discuss about various immunotechniques and their applications. The course covers discussions on the various components of the immune system, the activations of those components during immune response and the different types of immune responses. All the components of the immune system whether it’s the cells or organs, the different proteins or the various immuno mediators, they all work together to give a highly co-ordinated and interactive immune response to eliminate any foreign body that may be harmful to the body. The course also has discussions on some of the important immunotechniques like radioimmunoassay, ELISA, western blotting, fluorescence in situ hybridisation etc. It is a comprehensive course covering vast areas of immunology. On undergoing this course, the students will be learning the fundamental knowledge of immunology along with its importance and applications.

Summary

Course Status :	Completed
Course Type :	Core
Duration :	12 weeks
Category :	Biological Sciences & Bioengineering
Credit Points :	4
Level :	Undergraduate
Start Date :	15 Jul 2019
End Date :	05 Oct 2019
Exam Date :

Page Visits

Course layout

Week 1: Introduction to immune system, Organs of the immune system, Cells of the immune system, Antigens and immunogens

Week 2: Structures of immunoglobulins, Generation of antibody diversity, Antigen-antibody interactions, T-Cell receptors (TCR)

Week 3: MHC- molecules, Cytokines, Complement System –I Classical pathway, Complement System –II Alternative pathway

Week 4: Antigen processing and presentation ( Antigen presenting cells-macrophages, dendritic cells), Development of B cells and T cells, Types of immune response-I Innate and adaptive immunity, Types of immune response-II Humoral and cell mediated immunity

Week 5: , Types of immune response-III Primary and secondary immune response, Types of immune response-IV Clonal selection theory, Immunity to infection (Activation of B and T- cells),

Week 6: Immune response to viruses, Immune response to bacteria, Immune response to parasites

Week 7: Mediators of inflammation and leukocyte extravasations, Inflammation, Hypersensitivity reactions, Autoimmune diseases

Week 8: Immunodeficiency diseases, Transplantation immunology, Immunohaematology, Immunotolerance,

Week 9: Vaccine, Immunochemical technique-I : Production of antibodies, Immunochemical technique-II: Immunodiffusion testm, Immunochemical technique-III: Complement fixation test,

Week 10: Western blot analysis and Elisa, Immunochemical technique-V: Immuno- electrophoresis, Immunochemical technique-VI: Enzyme Linked Immunosorbant Assay (ELISA)

Week 11: Immunochemical technique-VII: Assaya based on agglutination reactions, Immunochemical technique-VIII: Purification of immunoglobulins, Immunochemical technique-IX: Isolation of lymphocytes and macrophages

Week 12: Discussion/Interaction

Books and references

REFERENCES:
Peter J. Delves, Seamus J. Martin, Dennis R. Burton & Ivan M Roitt. 2011: Roitt's essential immunology (12th ed) Hoboken, NJ: Wiley-Blackwell.

Kindt, T. J., Goldsby, R. A., Osborne, B. A., & Kuby, J. 2007: Kuby immunology (6th ed.). New York: W.H. Freeman

LINKS:

http://www.mcqbiology.com/2014/12/multiple-choice-questions-on-basic.html#.WTJzEdzYXIU

https://microbeonline.com/mcq-in-microbiology-immunology-questions-and-answers-with-explanation/

Instructor bio

Dr. Reena Haobam has been working as an Assistant Professor in the Department of Biotechnology, Manipur University since 2009. She was awarded the university gold medal in M.Sc. (Biochemistry) from Manipur University in 2002. Later, she received her Ph.D. Degree from Jadavpur University, Kolkata. She had worked in the Indian Institute of Chemical Biology (CSIR), Kolkata for her doctoral degree in the field of regenerative therapy for Parkinson’s disease using stem cells. Her research is mainly focused on the genomics of drug addiction and tuberculosis. She has successfully completed a DBT project on “Association of gene polymorphisms in DAT1 and OPRM1 with drug addiction in a population from Manipur”. At present she is handling two research projects: A multi-institutional DBT project on pharmacogenomics of Tuberculosis and genotyping of MDR-TB in north east India in which she is the project co-ordinator and PI. The other project is an IBSD-partnership programme where their research team works on identifying neuroprotective molecules from plant sources from the rich biodiversities of Manipur. She has many international research papers to her credit and has about 265 citations. She also has a US-patent application for “Treatment of brain Disorders”.